A smart innovative approach for delivery of nanosized risperidone to brain via novelistic trans vermillion route

Aim: Performance evaluation of Risperidone loaded bio-flexi films using Cucurbita pepo.
Research design and Methods: The risperidone loaded bio-flexi films was prepared using novel bio-film former isolated from fruit pulp of Cucurbita pepo by solvent casting method with different ratios (1%, 2%, 3%, 4%, 5% and 8%) and with standard polymer HPMC and CMC-Na (1%, 2%, 3%, 4% and 5%). The prepared formulations were evaluated for thickness, folding endurance, swelling index, content uniformity, in-vitro drug release, scanning electron microscopy (SEM), transmission electron microscopy (TEM), in-vitro cytotoxicity and stability studies.

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Author(s):

N V Satheesh Madhav1* and Bhavana Singh2

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