Dental materials are categorized as class 2 medical devices associated with moderate risk according to US Food and Drug Administration (USFDA). The aim of dental pharmacology is to understand the scientific aspects of how drugs and dental materials work within body systems. The different materials used in dentistry have their own beneficial as well as adverse effects. In order to make sure the biocompatibility of any material that is used in dentistry there is an organization named International Academy of Oral Medicine and Toxicology (IAOMT) that focuses mainly on making dental practice more biologically acceptable. Depending upon the duration of application, dental materials are classified as, temporary and permanent materials. It could be associated with mild, moderate or severe adverse events that should be reported as per regulatory requirement and materiovigilance. In order to prevent or overcome the toxic effects of these materials or drugs used in dentistry we need to focus more on “Biological dentistry” where in the well-being of the mouth is considered as an integral part of the health of the whole person.